Cushings Disease


Cushing’s disease, also known as PPID (pituitary pars intermedia dysfunction) is a progressive disorder that begins with the dysfunction of the pituitary gland. This gland at the base of the brain sends out a number of hormones, and a horse with Cushing’s disease starts to send out more hormones causing a number of symptoms.

The most common symptom is a long, curly hair coat that fails to shed during the change from winter to summer. Other symptoms include: excessive sweating, lethargy, poor athletic performance, infertility, muscle wasting (especially along the top line), abnormal fat distribution (accumulations in the crest of the neck, along the tail head, sheath, and above the eyes), delayed wound healing, increased susceptibility to infections, and increased water consumption with passage of large amounts of urine. Cushing’s tends to occur in middle-aged and older horses, around age twenty. Without treatment, symptoms tend to worsen over time and can be fatal. Symptoms are easily observed in advanced cases.


Cushing’s disease, is caused by a hormone-secreting tumor on the pituitary gland at the base of the horse’s brain. The tumor causes an over-production of hormones resulting in the observed symptoms.


Diagnosis of early cases or those characterized by few obvious clinical signs can be more difficult. There are two clinical tests available: 1) dexamethasone suppression test, and 2) plasma ACTH measurement test. Consult your veterinarian for the appropriate tests if you suspect your horse has Cushing’s disease.


These horses are often insulin resistant and have high blood sugar levels so non-structural carbohydrates (NSC, sugar and starch) need to be minimized. Feeding recommendations are to provide a total diet with less than 15% sugar and starch for most horses with Cushing’s disease. Pasture grasses can have high sugar content, especially during the spring and fall seasons. Since laminitis and founder are more common in horses with Cushing’s disease, pasture grazing should be severely limited or totally avoided. Regular exercise reduces blood glucose levels, so it will help horses with Cushing’s disease.

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